06131-17-7112
06131-17-6629
stephan.grabbe@unimedizin-mainz.de
PD Dr. Matthias Bros
Wiss. Angestellter
mbros@uni-mainz.de
Tel.: 06131-17-9846
Fax: 06131-17-9656
Evelyn Montermann
Technische Angestellte
monterma@uni-mainz.de
Tel.: 06131-17-9852
Ingrid Tubbe
Technische Angestellte
tubbe@uni-mainz.de
Tel.: 06131-17-9852
Monika Bednarczyk
Biologin / Doktorandin
monika.bednarczyk@unimedizin-mainz.de
Tel.: 06131-17-9852
Dominika Hobernik
Chemikern / Doktorandin
dhoberni@uni-mainz.de
Tel.: 06131-17-9818
Cinja Kappel
Biologin / Doktorandin
cinkappe@uni-mainz.de
Tel.: 06131-17-9818
David Paßlick
Biologe / Doktorand
dapassli@uni-mainz.de
Tel.: 06131-17-9818
Sarah Pittner
Biologin / Doktorandin
sarahpittner@kabelmail.de
Tel.: 06131-17-9846
Kristina Anthes-Stöcking
Studentin Humanmedizin /medizinische Doktorandin
kristinaanst@gmail.com
Tel.: 06131-17-9852
Frederic Fittler
Student Biomedizin- /Masterand
ffittler@students.uni-mainz.de
Tel.: 06131-17-9846
Hayat Tajouaoit
Studentin Biomedizinische Chemie / Diplomandin
htajouao@students.uni-mainz.de
Tel.: 06131-17-9846
Gebäude-Nr. 401 (Hautklinik)
Labor 153b (Labortrakt im ersten Stockwerk)
Tel: +49(0)6131-172909
Fax: +49(0)6131-175505
Hoffmann-Klose Stiftung (Funktionalisierte Nanopartikel als moderne Immuntherapeutika und Vakzine)
SFB 10 66-B04
SFB 10 66-B05
Balkow S, Heinz S, Schmidbauer P, Kolanus W, Holzmann B, Grabbe S, Laschinger M. LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming. Blood. 2010 Sep 16;116(11):1885-94
Krummen M, Balkow S, Shen L, Heinz S, Loquai C, Probst HC, Grabbe S. Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy. J Leukoc Biol. 2010 Jul;88(1):189-99
Varga G, Nippe N, Balkow S, Peters T, Wild MK, Seeliger S, Beissert S, Krummen M, Roth J, Sunderkötter C, Grabbe S. LFA-1 contributes to signal I of T-cell activation and to the production of T(h)1 cytokines. J Invest Dermatol. 2010 Apr;130(4):1005-12
Balkow S, Loser K, Krummen M, Higuchi T, Rothoeft T, Apelt J, Tuettenberg A, Weishaupt C, Beissert S, Grabbe S. Dendritic cell activation by combined exposure to anti-CD40 plus interleukin (IL)-12 and IL-18 efficiently stimulates anti-tumor immunity. Exp Dermatol. 2009 Jan;18(1):78-87
Balkow S, Krux F, Loser K, Becker JU, Grabbe S, Dittmer U. Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cells. Blood 2007; 110 (12): 3949-58
Varga G, Balkow S, Wild MK, Stadtbaeumer A, Krummen M, Rothoeft T, Higuchi T, Beissert S, Wethmar K, Scharffetter-Kochanek K, Vestweber D, Grabbe S. Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation. Blood. 2007 Jan 15;109(2):661-9. Epub 2006 Sep 26
Rothoeft T, Balkow S, Krummen M, Beissert S, Varga G, Loser K, Oberbanscheidt P, van den Boom F, Grabbe S. Structure and duration of contact between dendritic cells and T cells are controlled by T cell activation state. Eur J Immunol. 2006 Dec;36(12):3105-17
Riemann H, Loser K, Beissert S, Fujita M, Schwarz A, Schwarz T, Grabbe S. IL-12 breaks dinitrothiocyanobenzene (DNTB)-mediated tolerance and converts the tolerogen DNTB into an immunogen. J Immunol. 2005 Nov 1;175(9):5866-74
Gunzer M, Riemann H, Basoglu Y, Hillmer A, Weishaupt C, Balkow S, Benninghoff B, Ernst B, Steinert M, Scholzen T, Sunderkötter C, Grabbe S. Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral-blood leukocyte depletion. Blood. 2005 Oct 1;106(7):2424-32. Epub 2005 Jun 23
Gunzer M, Weishaupt C, Hillmer A, Basoglu Y, Friedl P, Dittmar KE, Kolanus W, Varga G, Grabbe S. A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo. Blood. 2004 Nov 1;104(9):2801-9. Epub 2004 Jul 15
Nashan D, Kocer B, Schiller M, Luger T, Grabbe S. Significant risk of a second melanoma in patients with a history of melanoma but no further predisposing factors. Dermatology. 2003;206(2):76-7
Grabbe S, Gunzer M. DC-T-cell synapses. Trends Immunol. 2002 Feb 1;23(2):66
Pendl GG, Robert C, Steinert M, Thanos R, Eytner R, Borges E, Wild MK, Lowe JB, Fuhlbrigge RC, Kupper TS, Vestweber D, Grabbe S. Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1. Blood. 2002 Feb 1;99(3):946-56
Grabbe S, Varga G, Beissert S, Steinert M, Pendl G, Seeliger S, Bloch W, Peters T, Schwarz T, Sunderkötter C, Scharffetter-Kochanek K. Beta2 integrins are required for skin homing of primed T cells but not for priming naive T cells. J Clin Invest. 2002 Jan;109(2):183-92
Gunzer M, Schaefer A, Borgmann S, Grabbe S, Zanker KS, Broeker EB, Kampgen E, Friedl P. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 2000: 323-332
Beissert S, Bluestone JA, Mindt I, Voskort M, Metze D, Mehling A, Luger TA, Schwarz T, Grabbe S. Reduced ultraviolet-induced carcinogenesis in mice with a functional disruption in B7-mediated costimulation. J Immunol. 1999 Dec 15;163(12):6725-31
Curiel-Lewandrowski C, Mahnke K, Labeur M, Roters B, Schmidt W, Granstein RD, Luger TA, Schwarz T, Grabbe S. Transfection of immature murine bone marrow-derived dendritic cells with the granulocyte-macrophage colony-stimulating factor gene potently enhances their in vivo antigen-presenting capacity. J Immunol. 1999 Jul 1;163(1):174-83
Bros, M., N. Dexheimer, R. Ross, Y. Höhn, J. Tampe, A. Sutter, F. Jährling, S. Grabbe and A.B. Reske-Kunz. 2011. Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation. Gene 472: 18-27.
Lausch, E., Janecke, A., Bros, M., Trojandt, S., Alanay, Y., de Laet, C., Hübner, C.A., Meinecke, P., Nishimura, G., Matsuo, M., Hirano, Y., Tenoutasse, S., Kiss, A., Machado Rosa, R.F., Unger, S.L., Renella, R., Bonafé, L., Spranger, J., Unger, S., Zabel, B. and Superti-Furga. 2011. A. Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity. Nat. Genet. 43:132-137
Bros, M., N. Dexheimer, V. Besche, N. Hövelmeyer, S. Reissig, S. Grabbe, A. Waisman and A.B. Reske-Kunz. 2010. Mutated cylindromatosis gene affects the functional state of dendritic cells. Eur. J. Immunol. 40: 2848-2857.
Sudowe, S., S. Dominitzki, E. Montermann, M. Bros, S. Grabbe and A.B. Reske-Kunz. 2009. Uptake and presentation of exogenous antigen and presentation of endogenously produced antigen by skin dendritic cells represent equivalent pathways for the priming of cellular immune responses following biolistic DNA immunization. Immunology 128 (1 Suppl.): e193-205.
Zindler, E., N. Gehrke, C. Luft, S. Reuter, C. Taube, S. Finotto, A.B. Reske-Kunz and S. Sudowe. 2008. Divergent effects of biolistic gene transfer in a mouse model of allergic airway infammation. Am. J. Respir. Cell. Mol. Biol. 38: 38-46.
Bros, M., F. Jährling, A. Renzing, N. Wiechmann, N.-A. Dang, A. Sutter, R. Ross, J. Knop, S. Sudowe and A.B. Reske-Kunz. 2007. A newly established murine dendritic cell line can be differentiated into a muture state, but exerts tolerogenic function upon maturation in the presence of glucocorticoid. Blood 109: 3820-3829.
Sudowe, S., I. Ludwig-Portugall, E. Montermann, R. Ross and A.B. Reske-Kunz. 2006. Prophylactic and therapeutic intervention in IgE responses by biolistic DNA vaccination primarily targeting dendritic cells. J. Allergy Clin. Immunol. 117: 196-203.
Ghadially, H., X.-L. Ross, C. Kerst, J. Dong, A.B. Reske-Kunz and R. Ross. 2005. Differential regulation of CCL22 gene expression in murine dendritic cells and B cells. J. Immunol. 174: 5620-5629.