Susanna Lopez Kostka, MTA
Dr. Peri Caucig, wiss. Mitarbeiterin
Stefanie Dinges, MTA
Andreas Eichhorn, biol. Doktorand 
Beate Lorenz, MTA
Sven Nowak, biol. Doktorand
Stephan Briem, med. Doktorand
Florian Butsch, med. Doktorand
Caroline Gazeau, med. Doktorandin
Boris Geiger, med. Doktorand
Anne Graics, med. Doktorandin
Jacek Sterinal, med. Doktorand
Daniel Teschner, med. Doktorand

Labor 161:
Tel.: +49-6131-172947

Labor 163:
Tel.: +49-6131-174523

Fax: +49-6131-175505

• Untersuchungen zur Rolle von dendritischen Zellen (DC) für die Entwicklung von Th1/Tc1-vermittelter Immunität gegen Leishmania major
• Identifikation von genetisch bedingten Unterschieden in der Freisetzung von Th1-induzierenden Zytokinen aus DC und deren Bedeutung für das Krankheitsbild
• Überprüfung der Unterschiede in anderen Th1-/Th2-Krankheitsbildern (z.B. allergisches Asthma, DTH, Kontaktallergie)

Sonderforschungsbereich 548, Teilprojekt A7 "Analyse der Beeinflussung von T-Helfer-Immunantworten durch proinflammatorische Zytokine am Beispiel der Leishmaniose und der Kontaktallergie" (2002-2009).

Sonderforschungsbereich 490, Teilprojekt D6 "Analyse der Interaktion von Leishmania major mit epidermalen Langerhanszellen/ dendritischen Zellen" (2003-2009)

Dr. Jürgen Manchot-Stiftung (Kollaboration mit Prof. Marcus Maurer, Univ.-Hautklinik Charite, Berlin) "Bedeutung von kutanen Mastzellen für die Entwicklung protektiver Immunantworten gegen Leishmania major" (2006-2008)

WHO, Special Programme for Research and Training in Tropical Diseases (TDR), Collaboration with Dr. Mark C. Udey, Dermatology Branch, NCI, National Institutes of Health, Bethesda, MD, USA "Vaccination against experimental cutaneous Leishmaniasis with protein antigen-transduced dendritic cells" (2002-2003)

VW-Foundation (Collaboration with Dr. Blaise Dondji, University of Ngaoundé, Cameroon & Prof. Marcus Maurer, Dept. of Dermatology, Charité Berlin) "Cutaneous Leishmaniasis in northern Cameroon: immunological studies of Leishmania and Leishmania/HIV co-infection in the Mokolo endemic focus"

• Dr. Yasmine Belkaid, Head Mucosal Immunology Unit, Laboratory of Parasitic Diseases, NIAID, NIH
• Dr. Genevieve Milon, Institut Pasteur, Paris, Frankreich
• Prof. Cord Sunderkötter, Univ.-Hautklinik Ulm
• Dr. Jan Ehrchen, Univ.-Hautklinik Münster
• Dr. Mark Udey, Dermatology Branch, NCI, NIH, Bethesda, MD, USA

1. Woelbing F, Kostka SL, Moelle K, Belkaid Y, Sunderkoetter C, Verbeek S, Waisman A, Nigg AP, Knop J, Udey MC, von Stebut E. Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity. J Exp Med. 2006 Jan 23;203(1):177-88
2. Lopez Kostka S, Knop J, Konur A, Udey MC, von Stebut E. Distinct roles for IL-1 receptor type I signaling in early versus established Leishmania major infections. J Invest Dermatol. 2006 Jul;126(7):1582-9.
3. Maurer M, Lopez Kostka S, Siebenhaar F, Moelle K, Metz M, Knop J, von Stebut E. Skin mast cells control T cell-dependent host defense in Leishmania major infections. FASEB J, in press.
4. Zahn S, Wirtz S, Birkenbach M, Blumberg RS, Neurath MF, von Stebut E. Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major. Eur J Immunol. 2005; 35: 1106-1112.
5. von Stebut E, Udey MC. Requirements for Th1-dependent immunity against infection with Leishmania major. Microbes Infect. 2004; 6:1102-9.
6. Maurer M, von Stebut E. Macrophage inflammatory protein-1. Int J Biochem Cell Biol. 2004; 36:1882-6.
7. von Stebut E, Belkaid Y, Lopez Kostka S, Knop J, Udey MC. Proinflammatory IL-1a induces Th1 differentiation and protective immunity in Leishmania-susceptible BALB/c mice via induction of IL-12. J Exp Med. 2003; 198:191-9.
8. von Stebut E, Metz M, Milon G, Knop J, Maurer M. Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1a/b released from neutrophils recruited by mast cell-derived TNFa. Blood. 2003; 101:210-5.
9. von Stebut E, Belkaid Y, Nguyen B, Wilson M, Sacks DL, Udey MC. Skin-derived macrophages from Leishmania major-susceptible mice exhibit IL-12- and IFNg-independent nitric oxide production and parasite killing after treatment with immunostimulatory DNA. J Invest Dermatol. 2002; 119:621-8.
10. Belkaid Y, von Stebut E, Mendez S, Lira R, Caler E, Bertholet S, Udey MC, Sacks DL. CD8(+) T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol 2002;168:3992-4000.
11. von Stebut E, Belkaid Y, Nguyen BV, Cushing M, Sacks DL, Udey MC. Leishmania major-infected murine langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis. Eur J Immunol. 2000;30:3498-506.
12. von Stebut E, Belkaid Y, Jakob T, Sacks DL, Udey MC. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. J Exp Med. 1998;188:1547-52.