Visual Universitätsmedizin Mainz

Research Team PD Dr. Christian Becker

Faculty:

PD Dr. rer. nat. Becker
Christian Becker, PD Dr. rer. nat.

+49 (0)6131-17-2917
+49 (0)6131-17-8277
+49 (0)6131-17-474523
christian.becker@unimedizin-mainz.de

Staff:

Melanie Schwenk, PhD student
Natascha Anna Maria Luther, PhD student
Dr. Christian Stanger (guest)
Ana Flávia Fernandes Ribas Nardy, PhD student (guest)
Philipp Hölter, technical assistant 
Franziska Krebs (graduand)

Contact:

Labor 147


Tel.: 06131 17-8147

Research fields:

  • molekular characterisation of T cell function
  • Development of T cell modulating agents

Publications (selected first and last author papers only):

Interferon-α Suppresses cAMP to Disarm Human Regulatory T Cells. 
Bacher N, Raker V, Hofmann C, Graulich E, Schwenk M, Baumgrass R, Bopp T, Zechner U, Merten L, Becker C*, Steinbrink K*.
Cancer Res. 2013 Sep 15;73(18):5647-56. doi: 10.1158/0008-5472.CAN-12-3788. Epub 2013 Jul 22. *shared senior authors

Angiotensin II-Induced Vascular Dysfunction Depends on Interferon-γ-Driven Immune Cell Recruitment and Mutual Activation of Monocytes and NK-Cells.
Kossmann S, Schwenk M, Hausding M, Karbach SH, Schmidgen MI, Brandt M, Knorr M, Hu H, Kröller-Schön S, Schönfelder T, Grabbe S, Oelze M, Daiber A, Münzel T, Becker C*, Wenzel P*.
Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1313-9. doi: 10.1161/ATVBAHA.113.301437 *shared senior authors

Repression of cyclic adenosine monophosphate upregulation disarms and expands human regulatory T cells.
Klein M, Vaeth M, Scheel T, Grabbe S, Baumgrass R, Berberich-Siebelt F, Bopp T, Schmitt E, Becker C.
J Immunol. 2012 Feb 1;188(3):1091-1097

CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease.

Martin H, Reuter S, Dehzad N, Heinz A, Bellinghausen I, Saloga J, Haasler I, Korn S, Jonuleit H, Buhl R, Becker C*, Taube C*.

J Allergy Clin Immunol. 2012 Feb;129(2):521-528 *shared senior authors

Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells.

Becker C, Taube C, Bopp T, Becker C, Michel K, Kubach J, Reuter S, Dehzad N, Neurath MF, Reifenberg K, Schneider FJ, Schmitt E, Jonuleit H.

Blood. 2009 Aug 6;114(6):1263-9.

Adoptive tumor therapy with T lymphocytes enriched through an IFN-gamma capture assay.

Becker C, Pohla H, Frankenberger B, Schüler T, Assenmacher M, Schendel DJ, Blankenstein T.

Nat Med. 2001 Oct;7(10):1159-62

Funding:

Bundesministerium für Bildung und Forschung, NMFZ, Deutsche Forschungsgemeinschaft
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